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Experimental Approaches to Biopharmaceutics and Pharmacokinetics
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This book aims to equip pharmacy graduate and post graduate students with the knowledge and skills required to conduct various experiments relevant to biopharmaceutics and pharmacokinetics. The focus is on providing information about how biopharmaceutical experiments are conducted and how pharmacokinetic parameters are determined. This edition includes appendices such as Definitions, Disintegration, Dissolution, Diffusion, Kinetic models, Statistical techniques, BABE Studies, Pharmacokinetics, Standard Solutions and Viva voce.
These chapters provide comprehensive information relevant to theoretical and practical aspects. A balanced mix of experiments and pertinent appendices has been provided to make the subject matter as clear and interesting to the reader as possible.
Salient Features · Nomograms · Kinetic models for dissolution studies · Statistical Techniques for appropriate interpretation of experimental data · Pharmacokinetic practice problems and exercises
· Standard Solutions and definitions.
Contents
Experiment 1: Calibration Curve of Salicylic Acid by Colorimetry, Experiment 2: Calibration Curve of Diclofenac Sodium by UV Spectrophotometry, Experiment 3: Linear Regression and Correlation Coefficient, Experiment 4: Disintegration of Tablets, Experiment 5: Dissolution of Conventional Tablets, Experiment 6: Dissolution of Enteric Coated Tablets, Experiment 7: Dissolution of Sustained Release (SR) Tablets, Experiment 8: Dissolution Study of Different Dosage Forms, Experiment 9: Effect of Polymorphism on Drug Dissolution, Experiment 10: Effect of Complexation on Solubility and Dissolution Rate, Experiment 11: Comparative Dissolution Studies of Marketed Products and Treatment of Data by using ANOVA, Experiment 12: In vitro Drug Diffusion from Ointment Bases, Experiment 13: In vitro Drug Permeation (Diffusion) Study of Ointment, Experiment 14: Protein Binding Studies, Experiment 15: In vitro Drug – Drug Interaction Studies, Experiment 16: Bioavailability and Bioequivalence Studies, Experiment 17: Determination of Creatinine Clearance by Nomogram Method (Height), Experiment 18: Determination of Creatinine Clearance by Nomogram Method (Weight), Experiment 19: One Compartment Open Model-IV Bolus, Experiment 20: One Compartment Open Model-IV Infusion, Experiment 21: One Compartment Open Model-Extravascular, Experiment 22: Two Compartment Open Model-IV Bolus, Experiment 23: Multidose Injections, Experiment 24: Multidose Extravascular
About the Authors
Dr. Suresh Bandari, Principal, St. Peter's Institute of Pharmaceutical Sciences, Hanamkonda, Warangal, A.P, India, had completed his Ph. D. from Kakatiya University under National Doctoral Fellowship of AICTE. He qualified GATE 2000 with 99.44 percentile (All India 18th rank) and received fellowship for M. Pharm. studies from University Grants Commission. He is the recipient of travel grants from Department of Science and Technology (DST), International Pharmaceutical Federation (FIP) to present research findings in various international conferences such as American Association of Pharmaceutical Scientists and Pharmaceutical Sciences World Congress of FIP. He is having more than ten years of research and teaching experience, had one patent and 35 publications in national and international journals with total impact factor of more than 30. He also received the Association of Pharmacy Professionals (APP) Young Scientist Award-2013. Vijay kumar Nagabandi, Assistant Professor, St. Peter's Institute of Pharmaceutical Sciences, Hanamkonda, Warangal, A.P, India, had completed his M. Pharmacy from Osmania University. He qualified GATE 2005 with 97.56 percentile and received fellowship for M. Pharm. studies from AICTE. He has submitted his Ph. D. dissertation to JNTU, Hyderabad. He secured university second rank at his B. Pharm. from Kakatiya University. He is the recipient of "The Indian Pharmaceutical Association - Shri Ramanbhai B. Patel Foundation - (IRF) International Travel Grant" to present research findings at American Association of Pharmaceutical Scientists (AAPS) Annual Meeting Exposition-2012. He is having six years of teaching and research experience and has published 13 papers of his research findings in various international and national reputed journals.Dr Raju Jukanti had completed his Ph. D. from Kakatiya University and received Junior and senior research fellowships from University Grants Commission. He secured all india 4th rank in GATE 1999 and received fellowship for M. Pharm. studies from University Grants Commission. He is the recipient of IDMA - G.P. Nair Award for outstanding performance in B. Pharm. He is the gold medalist at M. Pharm. He is having more than 35 publications in national and international journals with total impact factor of more than 30. He also presented his research findings at various national and international conferences.
These chapters provide comprehensive information relevant to theoretical and practical aspects. A balanced mix of experiments and pertinent appendices has been provided to make the subject matter as clear and interesting to the reader as possible.
Salient Features · Nomograms · Kinetic models for dissolution studies · Statistical Techniques for appropriate interpretation of experimental data · Pharmacokinetic practice problems and exercises
· Standard Solutions and definitions.
Contents
Experiment 1: Calibration Curve of Salicylic Acid by Colorimetry, Experiment 2: Calibration Curve of Diclofenac Sodium by UV Spectrophotometry, Experiment 3: Linear Regression and Correlation Coefficient, Experiment 4: Disintegration of Tablets, Experiment 5: Dissolution of Conventional Tablets, Experiment 6: Dissolution of Enteric Coated Tablets, Experiment 7: Dissolution of Sustained Release (SR) Tablets, Experiment 8: Dissolution Study of Different Dosage Forms, Experiment 9: Effect of Polymorphism on Drug Dissolution, Experiment 10: Effect of Complexation on Solubility and Dissolution Rate, Experiment 11: Comparative Dissolution Studies of Marketed Products and Treatment of Data by using ANOVA, Experiment 12: In vitro Drug Diffusion from Ointment Bases, Experiment 13: In vitro Drug Permeation (Diffusion) Study of Ointment, Experiment 14: Protein Binding Studies, Experiment 15: In vitro Drug – Drug Interaction Studies, Experiment 16: Bioavailability and Bioequivalence Studies, Experiment 17: Determination of Creatinine Clearance by Nomogram Method (Height), Experiment 18: Determination of Creatinine Clearance by Nomogram Method (Weight), Experiment 19: One Compartment Open Model-IV Bolus, Experiment 20: One Compartment Open Model-IV Infusion, Experiment 21: One Compartment Open Model-Extravascular, Experiment 22: Two Compartment Open Model-IV Bolus, Experiment 23: Multidose Injections, Experiment 24: Multidose Extravascular
About the Authors
Dr. Suresh Bandari, Principal, St. Peter's Institute of Pharmaceutical Sciences, Hanamkonda, Warangal, A.P, India, had completed his Ph. D. from Kakatiya University under National Doctoral Fellowship of AICTE. He qualified GATE 2000 with 99.44 percentile (All India 18th rank) and received fellowship for M. Pharm. studies from University Grants Commission. He is the recipient of travel grants from Department of Science and Technology (DST), International Pharmaceutical Federation (FIP) to present research findings in various international conferences such as American Association of Pharmaceutical Scientists and Pharmaceutical Sciences World Congress of FIP. He is having more than ten years of research and teaching experience, had one patent and 35 publications in national and international journals with total impact factor of more than 30. He also received the Association of Pharmacy Professionals (APP) Young Scientist Award-2013. Vijay kumar Nagabandi, Assistant Professor, St. Peter's Institute of Pharmaceutical Sciences, Hanamkonda, Warangal, A.P, India, had completed his M. Pharmacy from Osmania University. He qualified GATE 2005 with 97.56 percentile and received fellowship for M. Pharm. studies from AICTE. He has submitted his Ph. D. dissertation to JNTU, Hyderabad. He secured university second rank at his B. Pharm. from Kakatiya University. He is the recipient of "The Indian Pharmaceutical Association - Shri Ramanbhai B. Patel Foundation - (IRF) International Travel Grant" to present research findings at American Association of Pharmaceutical Scientists (AAPS) Annual Meeting Exposition-2012. He is having six years of teaching and research experience and has published 13 papers of his research findings in various international and national reputed journals.Dr Raju Jukanti had completed his Ph. D. from Kakatiya University and received Junior and senior research fellowships from University Grants Commission. He secured all india 4th rank in GATE 1999 and received fellowship for M. Pharm. studies from University Grants Commission. He is the recipient of IDMA - G.P. Nair Award for outstanding performance in B. Pharm. He is the gold medalist at M. Pharm. He is having more than 35 publications in national and international journals with total impact factor of more than 30. He also presented his research findings at various national and international conferences.
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